前沿科學

ATH-409, a selective and covalent ITK inhibitor, protects against atopic dermatitis in preclinical models

Identification of a highly selective ITK inhibitor which promotes Th1 differentiation and alleviate T cell exhaustion in vitro and in vivo

Lei Jiang; Zhiyong Yu; Xin Cheng; Baoying Cheng; Yuyao Zhang; Wenwen Zhao; Youxi Chen; Feng Zhou
Atheron Therapeutics (Shanghai), Ltd

Discovery of highly potent and selective KAT6A degraders that demonstrates robust anti-tumor activities in preclinical studies

Hanyu Wang, Lei Jiang, Youxi Chen, Baoying Cheng, Yuyao Zhang, Nianfeng Huang, Fan Yang, Feng Zhou
Atheron Therapeutics (Shanghai), Ltd

Discovery of first-in-class potent and selective oral CCNE1 molecule glues that show robust anti-tumor activities and better safety p

Zhiyong Yu; Wenming Li; Xiaoxiao Shi; Yuyao Zhang; Wenwen Zhao; Youxi Chen; Feng Zhou
Atheron Therapeutics, Ltd